This study published in the journal Thorax (2012;67(12):1046-1051) demonstrates that multifaceted allergen avoidance in infancy can help prevent the risk of asthma in childhood and up to age 18. The interventions studied included breast feeding on a low allergen diet, or using extensively hydrolysed formula(such as Alimentum or Nutramigen.) Dust mite avoidance was also performed through the use of environmental controls that included allergen-impermeable mattress and pillow encasings. The study found a significantly reduced risk of asthma in the active intervention group. Dr. Kenneth Backman of Allergy & Asthma Care comments: “This study helps demonstrate the effectiveness of allergen avoidance measures not just in reducing symptoms, but in actually preventing allergic diseases such as asthma.”

Background Asthma is a chronic disease that often starts in childhood. The key risk factors are a child’s environment and their genetic characteristics. The aim of this study was to evaluate the efficacy of environmental modification in the first 12 months of life on the prevalence of asthma in high-risk individuals. 

Methods Children (n=120) considered at high risk of allergic disorders (either dual heredity or single heredity and a high cord total IgE), were enrolled in a single-blinded, randomised controlled trial. Infants in the intervention arm were either breast fed with the mother on a low allergen diet or given an extensively hydrolysed formula. Exposure to house dust mite allergen was reduced. The control group followed standard advice. Children were assessed at ages 1, 2, 4, 8 and 18 years for the presence of asthma and atopy.

Results At 18 years of age, there was a significantly lower prevalence of asthma in the prevention group compared with the control group (OR: 0.23, 95% CI 0.08 to 0.70, p=0.01), primarily due to asthma that developed during childhood but persisted until age 18 years. Repeated-measure analysis showed that there was an overall reduction in asthma prevalence from 1 to 18 years (OR: 0.51, CI 0.32 to 0.81, p=0.04). Prevalence of atopy was not significantly different between the two groups at age 18.

Conclusion Comprehensive allergen avoidance in the first year of life is effective in preventing asthma onset in individuals considered at high risk due to heredity. The effect occurs in the early years, but persists through to adulthood.

Source: http://www.medscape.com/viewarticle/774797